Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine\n(NH3+) group of chitosan and the carboxylate (COOâË?â??) group of Carbopol. In situ polyelectrolyte complexes formations based\non the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The\naim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could\nmodify their technological performance in captopril tablets. The drug and excipients were evaluated as mixtures of powders and\ntablets. The mixtures with captopril contained Carbopol 974P NF, chitosan, or a 1 : 1 mixture thereof with polymer proportions of\n10%, 20%, and 30%. The evaluated parameters were the powder flow rate, the powder compressibility index, and the compactibility\nand release behavior of the tablets. The observed technological behavior points out to a greater interaction between the particles of\npolymers with different charge than between particles of the individual polymers. This produces more coherentmatrices restricting\nmore efficiently the drug dissolution, more coherent tablets with higher compactibility, and less flowing powder mixtures. All this,\nhowever, requires additional investigation to confirm the current results.
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